Fig. 1.
a) Graph show average median pharmacokinetic parameters. Blue - pre-bevacizumab; red = post-bevacizumab; Bev = bevacizumab; *** = significant; ns = not significant. b) Waterfall plot showing absolute change in Median Ktrans after bevacizumab across whole study population. c) Graph show significant negative correlation of absolute change in median Ktrans with pre-bevacizumab median Ktrans. d) Ktrans maps of eleven representative patients showing change in Ktrans after bevacizumab. Arranged in increasing reduction in Median Ktrans after bevacizumab. Pre-Bev = pre-bevacizumab; Post-Bev = post-bevacizumab; “P” = patient.