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Proposed Working Model for MOF in the Regulation of Meiotic Progression.
At early prophase I, MOF interacts with OSK1 to form an SCF complex E3 ligase complex that works together to promote early meiotic events, especially DSB processing and repair. Loss of function of MOF results in failure of homologous chromosome synapsis and recombination, which triggers meiotic arrest at late prophase I, and a prolonged arrest induces apoptosis and meiocyte elimination.
