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Heritability estimates using GCTA and a MAF stratification approach with the standard GRM when both disease prevalence and sex were taken into account
| Bin1: MAF < 0.1 | Bin 2: MAF 0.1–0.2 | Bin 3: MAF 0.2–0.3 | Bin 4: MAF 0.3–0.4 | Bin 5: MAF 0.4–0.5 | Sum | |
|---|---|---|---|---|---|---|
| TB cohort GRM | ||||||
| Heritability | 0.02 | 0.04 | 0.00 | 0.40 | 0.00 | 0.46 |
| SE | 0.01 | 0.16 | 0.18 | 0.20 | 0.16 | |
| STDB cohort GRM | ||||||
| Heritability | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.49 |
| SE | 0.25 | 0.38 | 0.39 | 0.40 | 0.39 | |
SNPs were divided into bins based on MAF.
