Table 3.
Single nucleotide polymorphisms (SNPs) for key genes of folate metabolism detected in CBA/J mice according to the Mouse Genome Project.
| Gene | Base in C57BL/6J | SNP | Base in CBA/J | Main change |
|---|---|---|---|---|
| Folr1 | G | rs47738978 | A* | 3’-UTR |
| A | rs47631647 | G* | missense F236L | |
| G | rs47445319 | A* | upstream 2KB | |
| A | rs49747152 | G* | upstream 2KB | |
| C | rs50854846 | A | intron | |
| C | rs52411810 | A | intron | |
| A | rs586270005 | T | intron | |
| C | rs52321323 | T | intron | |
| C | rs52448898 | A* | upstream 2KB | |
| G | rs240085681 | C | intron | |
| G | rs262701625 | A | intron | |
| Folr2 | C | rs32160123 | G* | intron |
| C | rs31011801 | T* | intron | |
| A | rs31275071 | C* | intron | |
| T | rs48667177 | A* | intron | |
| Bhmt2 | C | rs264842124 | T | downstream 500B |
| T | rs47046885 | C | 3’-UTR | |
| Mthfr | A | 148039163a | G* | unknown |
| G | 148039229a | C* | ||
| C | 148039557a | G | ||
| C | 148040119a | T | ||
| C | 148040240a | T | ||
| Mtrr | T | rs108123629 | t/a | 3’-UTR |
| C | rs108647820 | c/a | 3’-UTR | |
| G | rs108535269 | G | 3’-UTR | |
| T | rs108864771 | T | 3’-UTR | |
| Shmt1 | A | rs26957199b | G* | 3’-UTR |
| A | rs47721266 | C* | downstream 500B | |
| A | rs49213375 | C* | downstream 500B | |
| T | rs222704054 | C* | downstream 500B | |
| A | rs222753876 | G* | downstream 500B | |
| A | rs108000000 | G* | downstream 500B | |
| C | rs26957196 | A* | downstream 500B | |
| G | rs45981582 | A* | downstream 500B | |
| G | rs26957195 | A* | downstream 500B | |
| Shmt2 | G | rs252755979b | T* | 3’-UTR |
| C | rs240177349b | T* | 3’-UTR | |
| C | rs51081486b | T* | 3’-UTR | |
| A | rs47587430 | G* | 3’-UTR | |
| C | rs260368105 | T* | 3’-UTR | |
| G | rs49954613 | C* | 3’-UTR |
The table shows results of a search for SNPs in key genes of folate metabolism of CBA/J mice carried out in The Mouse Genome Project web page (http://www.sanger.ac.uk/science/data/mouse-genomes-project), where the C57BL76J strain is used as reference. *Multiple consequences, only the main one listed. aNumber indicates position. bGene assignment differs between MGP and NCBI databases.