Figure 2.

3D telomere organization of neuroblastoma cell lines. 3D telomere Q-FISH labels all telomeres (red) in the SHEP neuroblastoma cell line mock (A) and MYCN transfection (B) and the GIMEN neuroblastoma cell line mock (C) and MYCN transfection (D). Nuclei are counterstained with DAPI (blue). The distribution of telomere lengths for each condition is illustrated in a scatterplot (E) of the number of telomeres found at each relative fluorescence intensity interval measured: SHEP (gray) and GIMEN (black) cell lines after MYCN (solid lines) and mock (dashed lines) transfection.