Table 2.
Characteristics of the EGF System
| Univariate | Multivariate* | Score Value | Nonsquamous (n = 73) |
Squamous (n = 27) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage I & II (n = 12) |
Stage III & IV (n = 61) N (%) |
Stage I & II (n = 7) N (%) |
Stage III & IV (n = 20) N (%) |
|||||||||
| Biomarker | Cut Point | HR | CI | P Value | HR | CI | P Value | Initial Score | N† (%) | N† (%) | N† (%) | N† (%) |
| HER1 | 0.20 | 0.98 | 0.48-2.00 | .754 | 1.06 | 0.65-1.72 | .826 | − 1 | 1 (8) | 24 (39) | 3 (42) | 5 (25) |
| HER2 | 6.40 | 1.25 | 0.38-4.09 | .707 | 1.97 | 0.77-4.99 | .155 | + 1 | 0 | 4 (7) | 1 (14) | 0 |
| HER3 | 0.12 | 0.91 | 0.57-1.46 | .710 | 1.01 | 0.50-2.07 | .959 | − 1 | 0 | 9 (15) | 1 (14) | 2 (10) |
| AR | 1.03 | 2.03 | 0.93-4.44 | .077 | 1.34 | 0.81-2.22 | .254 | + 1 | 0 | 19 (31) | 0 | 6 (30) |
| EPI | 0.25 | 0.56 | 0.31-1.02 | .060 | 0.38 | 0.20-0.72 | .003 | − 1 | 1 (8) | 16 (26) | 0 | 2 (10) |
| HB-EGF | 1.20 | 1.92 | 1.11-3.31 | .018 | 1.86 | 0.96-3.59 | .065 | + 1 | 0 | 8 (13) | 2 (29) | 9 (45) |
| TGFα | 0.20 | 0.29 | 0.07-1.20 | .086 | 0.59 | 0.27-1.32 | .203 | − 1 | 1 (8) | 8 (13) | 1 (14) | 2 (10) |
| EGF | 0.35 | 0.22 | 0.05-0.91 | .037 | 0.99 | 0.55-1.78 | .991 | − 1 | 1 (8) | 14 (23) | 3 (43) | 2 (10) |
| The initial score‡ | 2.31 | 1.26-4.56 | .008 | 2.17 | 1.11-4.22 | .02 | ||||||
| The optimized score‡ | 3.70 | 2.26-8.08 | .00001 | 2.62 | 1.49-4.61 | .001 | 0 (0) | 12 (20) | 1 (14) | 8 (40) | ||
*
Multivariate results are adjusted for age, sex, PS, stage, and histology.
†
Number of patients with upregulated biomarker.
‡
Results are presented with bias-corrected interval.