Table 4.

Changes in Anatomical and Volumetric Functional Metrics Early (1 month) after IAT for the 2 Readers for Targeted Lesions (N = 42)

Reader 1					Reader 2
Parameter	Before Treatment	After Treatment	Mean percentage change (%)	P value*	Before Treatment	After Treatment	Mean percentage change (%)	P value*
Anatomical metrics
RECIST (cm)	4.3±3.4	4.5±3.6	4.2±6.3	0.4	4.2±3.4	4.4±3.6	4.3±7.7	0.3
mRECIST(cm)⁎⁎	3.3±3.3	2.8±3.4	− 16.9±2.2	0.01	3.1±3.2	2.4±3.3	− 22.8±3.8	0.005
EASL (cm2)⁎⁎	14.8±33.3	12.3±32.5	− 16.8±2.5	0.02	13.5±32.7	10.8±32.2	− 20.6±1.7	0.02
Volumetric metrics
Hepatic Arterial (%)	31.4±25.1	23.9±24.5	− 23.9±2.3	0.14	31.5±25.2	23.9±24.5	− 24.2±2.9	0.14
Portal Venous (%)	63.8±33.8	43.1±28.7	− 32.4±15.3	0.0001	63.6±34.2	42.6±28.3	− 33.0±17.0	< 0.0001
ADC (× 10− 3 mm2/s)⁎⁎⁎	1.408±.0353	1.592±0.383	13.1±8.5	0.0007	1.413±0.358	1.571±0.392	11.2±9.3	0.003

Note. Unless otherwise indicated, data are means ± standard deviations. *P value is obtained from independent-samples t test.

^⁎⁎mRECIST and EASL could not be measured in 7 (17%) lesions by Reader 1 and 9 (21%) lesions by Reader 2.

^⁎⁎⁎ADC map was not available in 5 targeted lesions.