Table 2.

The top 20 differentially methylated positions identified in the well high‐risk individuals who developed a mood disorder (ill later [IL]) compared to the well high‐risk individuals who remained well (well later [WL]), ranked by uncorrected P‐value

Probe ID	Gene symbol	Chr.	Coordinatea	P‐value	WL β (mean)	IL β (mean)	β differenceb
cg07398767	CA10	17	50237205	3.72×10−6	0.384	0.332	−0.053
cg08292919	GABBR1	6	29565696	4.22×10−6	0.900	0.880	−0.020
cg18995182	COL4A5; COL4A6	X	107682860	4.62×10−6	0.386	0.350	−0.036
cg19006127	—	4	3794737	5.97×10−6	0.205	0.187	−0.018
cg08608800	ZC3H13	13	46626937	6.91×10−6	0.159	0.138	−0.021
cg19199483	—	13	111483035	1.26×10−5	0.960	0.954	−0.007
cg01642827	GET4	7	925664	1.30×10−5	0.919	0.910	−0.009
cg03773183	—	17	79325994	1.33×10−5	0.781	0.854	0.074
cg01724150	NMNAT3	3	139397363	1.64×10−5	0.413	0.347	−0.066
cg26893134	FRK	6	116381904	1.73×10−5	0.914	0.893	−0.021
cg06927864	IL1RAPL1	X	28604661	1.77×10−5	0.278	0.343	0.065
cg19298821	C5orf48	5	125967357	2.00×10−5	0.918	0.932	0.013
cg00662273	PDPK1	16	2648122	2.03×10−5	0.932	0.921	−0.011
cg10827045	PPT1	1	40562842	2.09×10−5	0.092	0.101	0.009
cg06352873	DCBLD2	3	98596709	2.33×10−5	0.841	0.821	−0.020
cg08883995	MGMT	10	131389152	2.37×10−5	0.911	0.923	0.012
cg24507551	GTF2H4	6	30877958	2.67×10−5	0.896	0.908	0.011
cg08187750	PIWIL1	12	130824529	2.68×10−5	0.674	0.620	−0.055
cg02328223	MGLL	3	127541927	3.08×10−5	0.097	0.110	0.013
cg15171911	TCF4	18	53068921	3.11×10−5	0.713	0.671	−0.042

^aGRCh37/hg19.

^bIL β mean–WL β mean.

CA10: Carbonic Anhydrase 10; GABBR1: Gamma‐Aminobutyric Acid Type B Receptor Subunit 1; COL4A5: Collagen Type IV Alpha 5; COL4A6: Collagen Type IV Alpha 6; ZC3H13: Zinc finger CCCH domain‐containing protein 13; GET4: Golgi To ER Traffic Protein 4; NMNAT3: Nicotinamide Nucleotide Adenylyltransferase 3; FRK: Fyn Related Src Family Tyrosine Kinase; IL1RAPL1: Interleukin 1 Receptor Accessory Protein Like 1; C5orf48: Chromosome 5 Open Reading Frame 48; PDPK1: 3‐Phosphoinositide Dependent Protein Kinase 1; PPT1: Palmitoyl‐Protein Thioesterase 1; DCBLD2: Discoidin, CUB And LCCL Domain Containing 2; MGMT: O‐6‐Methylguanine‐DNA Methyltransferase; GTF2H4: General Transcription Factor IIH Subunit 4; PIWIL1: Piwi Like RNA‐Mediated Gene Silencing 1; MGLL: Monoglyceride Lipase; TCF4: Transcription Factor 4.