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. 2016 May 19;5(7):e1188243. doi: 10.1080/2162402X.2016.1188243

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Figure 4. — Association between the change in regulatory T cell (Treg) frequency in peripheral blood mononuclear cells (PBMCs) after FOLFIRI therapy and overall survival (OS) in patients with colorectal cancer. Patients were categorized based on any decrease or increase in Treg frequency after 30 d of FOLFIRI therapy. (A) A Kaplan–Meier curve is shown for these two groups and the association with OS. The median OS for patients with decreased Tregs after 30 d treatment was 43.3 mo, and for patients with increased Tregs after treatment, OS was 23.3 mo (p = 0.036, n = 23). The change in Treg frequency was found to be an independent predictive variable for OS by stepwise multiple regression analysis. (B) The median decrease in Treg frequency was −26%. (C) The median increase in Treg frequency was +23%.