Table 4.

Multiple regression analysis of variables associated with overall survival.

Variable	Standardized regression coefficient	Standard error	p value
Tregs at baseline	0.506	0.175	0.015
LDH	0.628	0.220	0.016
Change in Tregs at 30 d	0.443	0.194	0.043
Mucinous vs. non-mucinous	−0.252	0.176	0.181
Metastases	−0.223	0.167	0.209
ALP	−0.197	0.188	0.315
Age	0.164	0.184	0.392
Grade	−0.118	0.170	0.500
CEA	−0.066	0.344	0.851
Gender	0.033	0.192	0.866
CA19.9	0.005	0.341	0.988
Forward Stepwise Method
LDH	0.500	0.139	0.002
Tregs at baseline	0.467	0.142	0.004
Change in Tregs at 30 d	0.454	0.143	0.006
Mucinous vs. non-mucinous	−0.249	0.139	0.091
Metastases	−0.200	0.139	0.168

Metastases were categorized as 1. Liver vs. 2. liver + other sites vs. 3. Other sites.

Tregs, regulatory T cells; LDH, lactate dehydrogenase; ALP, alkaline phosphatase; CEA, carcinoembryonic antigen.