Table 3.
Univariate and multivariate analyses of factors associated with survival and recurrence.
| OS |
DFS |
|||||||
|---|---|---|---|---|---|---|---|---|
| Multivariate |
Multivariate |
|||||||
| Variables | Univariate p | HR | 95% CI | p | Univariate p | HR | 95% CI | p |
| Age, y (>58/≤58) | .162 | NA | .519 | NA | ||||
| Gender (female/male) | .763 | NA | .674 | NA | ||||
| Tumor stage (pT4/pTis + pT1 + pT2 + pT3) | < .001 | .946 | .463–1.932 | .878 | .006 | .708 | .307–1.629 | .416 |
| Nodal status (pN1 + pN2/pN0) | < .001 | 2.747 | 1.000–7.546 | .050 | < .001 | 5.081 | 1.109–23.290 | .036 |
| Distant metastases (Pos/Neg) | < .001 | 3.153 | 1.657–5.998 | < .001 | < .001 | 3.213 | 1.489–6.933 | .003 |
| Differentiation(H+M/L) | .024 | .459 | 0.252–.837 | .011 | .086 | NA | ||
| No. of lymph nodes analyzed (>12/≤12) | .074 | NA | .193 | NA | ||||
| Location (rectal/colon) | .193 | NA | .674 | NA | ||||
| CD169CD8PLN/CD169CD8DLN patterns | < .001 | .262 | .162–.424 | < .001 | < .001 | .443 | .265–.742 | .002 |
Note: Cox proportional hazards regression model; Variables associated with survival by univariate analysis were adopted as covariates in multivariate analyses.
Abbreviations: OS, overall survivial; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; NA, not applicable; Pos, positive; Neg, negative; PLN, peri-tumor lymph node; DLN, distant-tumor lymph node.
‡CD169CD8PLN/CD169CD8DLN are stratified into three groups (HiHi, LoLo, Het).