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. 2016 Apr 21;5(7):e1171446. doi: 10.1080/2162402X.2016.1171446

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — Readout of tumor graft trial. (A) Mice immunized with either rHER-2, DMD4 or DMD6 particles display significantly slower and smaller tumor growth compared to naive mice and mice immunized with wtAAV only. Tumor growth curve of grafted HER-2 overexpressing D2F2/E2 cells; at day 12, DMD4 immunized mice had significantly smaller tumors compared to those of the naive (p < 0.01) and of the wtAAV group (p < 0.05). DMD6 treated mice also developed significantly smaller tumors (p < 0.05 compared to naive group, p < 0.05 compared to wtAAV). Mice immunized with rHER-2 also developed significantly smaller tumors compared to both wtAAV treated (p < 0.01) or naive mice (p < 0.01). Tumor size at day 12 was analyzed by One-way ANOVA alongside Tukey's post-test; displayed are mean tumor volume values ± standard error of the mean (SEM). (B) Representative macroscopic pictures of explanted tumors. (C) Tumors of mice immunized with mimotope DMD6 or rHER-2 had significantly lower weight compared to tumors of animals receiving wtAAV. Diagram displaying weight of explanted tumors in grams; Box and whiskers plot, whiskers displaying minimum and maximum values (eight mice/group). Analysis by means of Kruskal–Wallis test and Dunns post-test.