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Pharmacodynamic changes during ipilimumab therapy. Expression of eomes on CD4+ and CD8+ T cells (A), T-bet (B) and CD122 (C) on. Cytotoxic markers expression (GzmB and TNF-a) on CD8+ T cells (D). Evolution of chemokine receptor expression in T cells (E). Note: T-bet and GzmB were evaluated on 20 patients as mentioned in material and method section. *for p < 0.05, ** for p < 0.01, *** for p < 0.001 and **** for p < 0.0001.
