Table 3. Number needed to treat throughout studies.
| Researcher, year of publication (reference) | Bevacizumab dose | NNT for response | NNTB and NNTH–survival | |
|---|---|---|---|---|
| At 12 months | At 24 months | |||
| Kabbinavar et al., 2003 (22) | 5 mg/kg; 10 mg/kg | 4; 14 | NNTB 9 (6–20) | NNTB 6 (5–11) |
| Moehler et al., 2009 (23) | 7.5 mg/kg | 20 | NNTH 100 (NNTH 4 to ∞ to NNTB 4) | NNTB 7 (NNTB 2 to ∞ to NNTH 6) |
| Hurwitz et al., 2005 (24) | 5 mg/kg | 33 | NNTB 10 (NNTB 4 to ∞ to NNTH 29) | NNTB 10 (NNTB 4 to ∞ to NNTH 34) |
| Hurwitz et al., 2004 (25) | 5 mg/kg | 10 | - | - |
| Saltz et al., 2008 (26) | 7.5 mg/kg; 5 mg/kg | RR equal (38%) | NNTB 16 (9–63) | NNTB 34 (NNTB 12 to ∞ to NNTH 43) |
| Stathopoulos et al., 2010 (27) | 7.5 mg/kg | 63 | NNTH 40 (NNTH 8 to ∞ to NNTB 13) | NNTH 9 (NNTB 48 to ∞ to NNTH 4) |
| Kabbinavar et al., 2005 (28) | 5 mg/kg | 9 | NNTB 10 (NNTH 31 to ∞ to NNTB 4) | NNTB 21 (NNTH 28 to ∞ to NNTB 7) |
| Guan et al., 2011 (29) | 5 mg/kg | 6 | NNTB 7 (NNTB 4 to ∞ to NNTH 1250) | NNTB 34 (NNTB 6 to ∞ to NNTH 10) |
| Giantonio et al., 2007 (30) | 10 mg/kg | 7 | NNTB 8 (5–21) | NNTB 14 (7–158) |
| Tebutt et al., 2010 (31) | 7.5 mg/kg | 13; 6 | NNTB 15 (NNTB 6 to ∞ to NNTB 27); NNTB 1000 (NNTB 9 to ∞ to NNTH 10) | NNTB 167 (NNTB 9 to ∞ to NNTB 10); NNTH 43 (NNTH 8 to ∞ to NNTB 12) |
| Cunningham et al., 2013 (32) | 7.5 mg/kg | 11 | NNTB 8 (4–53) | NNTB 10 (5–57) |
| Passardi et al., 2015 (33) | 5 mg/kg | 167 | NNTH 13 (NNTH 6 to ∞ to NNTB 101) | NNTH 35 (NNTH 8 to ∞ to NNTB 14) |
Abbreviations: NNT = Number needed to treat; RR = Response rate; NNTB = Number needed to treat to benefit; NNTH = Number needed to treat to harm.