Fig 3. Histopathological analysis of skin and lymph nodes of C57BL/6 mice footpads infected with Leishmania (L.) amazonensis and treated with Morinda citrifolia fruit juice, Noni.

Noni group treated at 500mg.kg^-1.day^-1 and Glucantime group treated at 20mg.kg^-1.twice a week^-1; both treatments were for 60 days. At 30 days: amastigotes within macrophages (arrows in inserts) and inflammatory infiltration in dermis of all groups. At 60 days: inflammatory infiltration decreased in the Noni group, and absence of amastigotes in the Noni and Glucantime groups. La group with intense inflammatory infiltration of macrophages with parasites at the lesion site. In lymph nodes, there was a decrease of the lymphoid nodules (asterisks) hyperplasia in Noni and Glucantime groups. Images representative of two experiments realized in triplicate. Hematoxylin-eosin.