Table 3.
Brain Regions Which Modulate Delay Based Choice Behavior
| Brain Region | Manipulation | Method/Drug | Result | Reference |
|---|---|---|---|---|
| mPFC | D1/D5 antagonism | SCH-23390 (D1) | ↓ delayed choice | Loos et al., 2010 |
| mPFC | D1/D5 agonism | SKF 38393 | ↓ delayed choice | Loos et al., 2010 |
| mOFC | Bilateral Inactivation | Muscimol (GABA A) Baclofen (GABA B) |
No effect | Stopper et al., 2014 |
| OFC | Lesion | Quinolinic acid | ↓ delayed choice | Mobini et al. 2002 |
| OFC | Lesion | ↑ delayed choice | Winstanley et al. 2004 | |
| OFC | Lesion | Quinolinic acid | ↓ delayed choice | Rudebeck et al., 2006 |
| OFC | Lesion | Muscimol (GABA A) Baclofen (GABA B) |
Dependent on Cue/baseline behavior | Zeeb et al., 2010 |
| OFC | DA Lesion | 6-OHDA | ↑ delayed choice | Kheramin et al. 2004 |
| OFC | D2 antagonism - No cue | Eticlopride (D2) | No effect | Zeeb et al., 2010 |
| OFC | D1 antagonism -No cue | SCH-23390 (D1) | No effect | Zeeb et al., 2010 |
| OFC | D2 antagonism- Cue | Eticlopride (D2) | ↓ delayed choice | Zeeb et al., 2010 |
| OFC | D1 antagonism -Cue | SCH-23390 (D1) | ↓ delayed choice | Zeeb et al., 2010 |
| BLA | Bilateral Inactivation | Quinolinic acid | ↓ delayed choice | Winstanley et al. 2004 |
| STN | Lesion | Ibotenic acid | ↑ delayed choice | Winstanley et al. 2005 |
| STN | Lesion | Ibotenic acid | ↑ delayed choice | Uslaner et al., 2006 |
| STN | Lesion | Quinolinic acid | ↓ delayed choice | Bezzina et al., 2009 |
| NAcc | DA Lesion | 6-OHDA | No effect | Winstanley et al., 2005 |