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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Mol Microbiol. 2016 Jun 10;101(3):495–514. doi: 10.1111/mmi.13404

Fig. 2. S. aureus prioritizes amino acid uptake in response to reductions in CodY activity.

Fig. 2

All data here and in subsequent figures are presented as the means of at least two independent experiments. RNA-Seq data are shown; % maximal expression relative to the codY null mutant (SRB372, None) is plotted across strains producing varying amounts of CodY regulatory activity: CodYWT, SRB337; CodYR61K, SRB506; CodYR61H, SRB623; CodYR61E, SRB577; CodYG129D, SRB493. In each panel, genes for nutrient transport are more sensitive to changes in CodY activity and reach 100% prior to genes for nutrient biosynthesis. A. CodY-repressed genes coding for the uptake (brnQ2, QV15_01265) and synthesis (ilvD) of ILV. B. CodY-repressed genes coding for the uptake (proposed histidine transporter, QV15_01335) and synthesis (hisB) of histidine. C. CodY-repressed genes coding for the uptake (metNIQ1 [QV15_01935-01945], metNIQ2 [QV15_04055-04065]) and synthesis (metE) of methionine.