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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Dev Biol. 2016 Jul 6;417(1):40–49. doi: 10.1016/j.ydbio.2016.07.004

Figure 7. Model of Celsr1 function in repressing rostral migration of FBM neurons.

Figure 7

We propose that Wnt5a, which is expressed along the midline in r3 and more anterior regions of the hindbrain, can act as a chemoattractive cue to facilitate the migration of FBM neurons located in anterior r4, adjacent to the r3/r4 boundary, rostrally into r3 and r2. A, In a wild type hindbrain, Celsr1 expression in the ventricular zone inhibits Wnt5a-dependent activation through an unknown mechanism (?), blocking the rostral migration of FBM neurons into r3. B, In a Celsr1-deficient hindbrain, the inhibition is relieved and FBM neurons migrate rostrally into r3 toward the Wnt5a source.