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. Author manuscript; available in PMC: 2016 Aug 31.
Published in final edited form as: Cancer Control. 2011 Jul;18(3):196–203. doi: 10.1177/107327481101800307

Fig 2.

Fig 2

Schematic representing intrinsic and extrinsic apoptosis initiation. When activated, p53 activates Bax and Bak, then Suma and Nova, leading to Apaf1 cleavage of pro-caspase 9 into active caspase 9. Bcl-2, along with BclXL and MCL1, can downregulate the activation of cytochrome C, halting proapoptotic signals from the intrinsic pathway. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and potentially other activation methods of extrinsic apoptosis remain active in synovial sarcoma.