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. Author manuscript; available in PMC: 2016 Aug 31.
Published in final edited form as: Cell Rep. 2016 Aug 18;16(9):2308–2316. doi: 10.1016/j.celrep.2016.07.079

Figure 3. Dynamic CENP-A localization defines DNA to be retained and eliminated.

Figure 3

A. CENP-A localization in the mitotic regions of germline (testis and ovary) and 4-cell embryos. CENP-A enriched regions (positive values) are in green and CENP-A depleted regions (negative values) in red (z-scores; see Supplemental Experimental Procedures). The purple arc and light blue shading represent the genomic region that will be eliminated. Circles from outer to inner represent: (1) Genes (red + strand and blue – strand); (2) Testis CENP-A; (3) Ovary CENP-A; and (4) 4-cell embryo CENP-A. B. CENP-A peaks are reduced prior to DNA elimination in regions of the genome that will undergo elimination. Changes in CENP-A peaks between the germline and 4-cell embryos in a region eliminated (scaffold ag84) (see Fig. 3C for the overall changes). C. CENP-A is reduced before DNA elimination (see also Table S1). CENP-A is present at high levels in the mitotic germline (Testis-1 and Ovary-1) within regions that will become eliminated in embryos and then is greatly reduced before DNA elimination (4-cell).