*Complete blood count, basic metabolic panel, liver function tests, amylase, lipase, endocrine function, coagulation profile, CT/MRI, EUS. †Patients with hereditary pancreatitis, family history of pancreatic cancer or familial cancer syndromes revert to respective pathway above. **Consider additional biomarker screening. CA, carbohydrate antigen; CEA, carcinoembryonic antigen; CT, computed tomography; EUS, endoscopic ultrasound; MRI, magnetic resonance imaging; TPIAT, total pancreatectomy with islet autotransplantation.