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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Pharm Res. 2016 Jun 28;33(10):2540–2551. doi: 10.1007/s11095-016-1978-1

Figure 2. NCI/ADR-RES spheroid growth.

Figure 2

Figure 2

(a) Spheroid diameter with age (Mean ± S.D., n=3) (b) H&E stained sections of NCI/ADR-RES spheroids by fluorescence microscopy. From day 7 onward, the formation of a distinctly stained core (indicated by arrow) became visible. Day 10 spheroids showed 2 distinct layers consisting of a proliferative outer shell and the necrotic inner core. By day 12, the spheroids had begun shedding cells on the periphery.