Table 1.
Affinity profiles of sst analogues
| Peptide | sstr1 | sstr2 | sstr3 | sstr4 | sstr5 |
|---|---|---|---|---|---|
| DOTATOC | >10,000 | 14 ± 2.6 | 880 ± 324 | >1,000 | 393 ± 84 |
| DOTATATE | >10,000 | 1.5 ± 0.4 | >1,000 | 453 ± 176 | 547 ± 160 |
| DOTALAN | >10,000 | 26 ± 3.4 | 771 ± 229 | >10,000 | 73 ± 12 |
| Ga-DOTATOC | >10,000 | 2.5 ± 0.5 | 613 ± 140 | >1,000 | 73 ± 21 |
| Ga-DOTATATE | >10,000 | 0.2 ± 0.04 | >1,000 | 300 ± 140 | 377 ± 18 |
| Ga-DOTANOC | >10,000 | 1.9 ± 0.4 | 40.0 ± 5.8 | 260 ± 74 | 7.2 ± 1.6 |
| Y-DOTATOC | >10,000 | 11 ± 1.7 | 389 ± 135 | >10,000 | 114 ± 29 |
| Y-DOTATATE | >10,000 | 1.6 ± 0.4 | >1,000 | 523 ± 239 | 187 ± 50 |
| Y-DOTANOC | >1,000 | 3.3 ± 0.2 | 26 ± 1.9 | >1,000 | 10.4 ± 1.6 |
| Y-DOTALAN | >10,000 | 22.8 ± 4.9 | 290 ± 105 | >10,000 | 16.3 ± 3.4 |
The table lists the values for the inhibitory constant (nmol/L) for sstr-binding peptides and their gallium and yttrium complexes. The IC50-value indicates the concentration when 50 % of binding is inhibited