Fig. 1.

BD improves body weight and glucose tolerance. A: BD mouse model. Cholecystoenterostomy is performed, and bile is drained to the distal jejunum (arrow). B: photograph of gallbladder-jejunal anastomosis. C: intraperitoneal glucose tolerance tests (IPGTTs) were performed at 2 wk postsurgery. *BD vs. WMS at 30, 60, 90, and 120 min, P < 0.05. D: area under the curve of IPGTT at 2 wk postsurgery. *BD vs. WMS, P < 0.05; **LFD, WMS, and BD vs. DIO, P < 0.01 (n = 5 per group). BD, bile diversion; DIO, diet-induced obesity; LFD, low-fat diet; WMS, weight-matched animals that underwent sham surgery.