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. 2016 Jun 23;311(2):G286–G304. doi: 10.1152/ajpgi.00202.2016

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Fig. 10. — BD enhances energy expenditure and promotes thermogenesis. A: energy expenditure: 24-h oxygen consumption (n = 5 per group). B: energy expenditure: day and night oxygen consumption. Daytime, *BD vs. WMS P < 0.05; ***BD vs. DIO, P < 0.001; #WMS vs. DIO, P < 0.05. Nighttime, ***BD vs. DIO and WMS, P < 0.001, n = 5 per group. C: TGR5, type-2 iodothyronine deiodinase (D2), and thermogenic genes in eWAT. **BD vs. TGR5, LFD, and DIO, P < 0.01; D2, **BD vs. LFD, DIO, and WMS, P < 0.01; uncoupling protein 1 (UCP1), *BD vs. DIO, P < 0.05; PGC-1α, **BD vs. LFD and DIO, P < 0.01; PR domain-containing 16 (PRDM16), **BD vs. LFD, DIO, and WMS, P < 0.01; and platelet-derived growth factor receptor-α (PDGFRα), **BD vs. LFD, DIO, and WMS, P < 0.01. D: TGR5, D2, and thermogenic genes in iWAT. *BD vs. TGR5 and LFD, P < 0.05; BD vs. DIO, P < 0.01; D2, **BD vs. DIO, P < 0.01; UCP1, **BD vs. DIO, P < 0.01; BD vs. PGC-1α, LFD, WMS, and DIO, P < 0.01; and BD vs. PDGFRα, LFD, DIO, and WMS, P < 0.01. E: there is no statistical differences among all groups (P < 0.05 except D2, WMS vs. DIO, P < 0.01). All values are presented as means ± SE.

Fig. 10. — BD enhances energy expenditure and promotes thermogenesis. A: energy expenditure: 24-h oxygen consumption (n = 5 per group). B: energy expenditure: day and night oxygen consumption. Daytime, *BD vs. WMS P < 0.05; ***BD vs. DIO, P < 0.001; #WMS vs. DIO, P < 0.05. Nighttime, ***BD vs. DIO and WMS, P < 0.001, n = 5 per group. C: TGR5, type-2 iodothyronine deiodinase (D2), and thermogenic genes in eWAT. **BD vs. TGR5, LFD, and DIO, P < 0.01; D2, **BD vs. LFD, DIO, and WMS, P < 0.01; uncoupling protein 1 (UCP1), *BD vs. DIO, P < 0.05; PGC-1α, **BD vs. LFD and DIO, P < 0.01; PR domain-containing 16 (PRDM16), **BD vs. LFD, DIO, and WMS, P < 0.01; and platelet-derived growth factor receptor-α (PDGFRα), **BD vs. LFD, DIO, and WMS, P < 0.01. D: TGR5, D2, and thermogenic genes in iWAT. *BD vs. TGR5 and LFD, P < 0.05; BD vs. DIO, P < 0.01; D2, **BD vs. DIO, P < 0.01; UCP1, **BD vs. DIO, P < 0.01; BD vs. PGC-1α, LFD, WMS, and DIO, P < 0.01; and BD vs. PDGFRα, LFD, DIO, and WMS, P < 0.01. E: there is no statistical differences among all groups (P < 0.05 except D2, WMS vs. DIO, P < 0.01). All values are presented as means ± SE.