Figure 4.

DSS treatment did not induce typical signs of DSS colitis in contaminated mice. (a) Body weight of mice (8 weeks old) contaminated with A. sydowii did not lose weight compared to mice harboring regular mouse SPF microbiota (n = 4/group, 2/cage). Inset plot: water content in each cage water bottle indicates that all mice consumed the same amount of DSS supplemented water. (b) Postmortem after DSS experiment. Note the small liver and large spleen and cecum (left) in A. sydowii mice as it is expected in mice in GF conditions. (c) Note the expected reduction in cecum size in SPF mice after DSS treatment due to diarrhea and appetite loss.