Figure 1.

Tumor microenvironment (TME) as a fertile ground for dynamic cell phenotype and function. Composition of TME implies immediate vicinity of mesenchymal stromal/stem cells (MSCs), tumor-associated fibroblasts (TAFs); immune cells: macrophages (MФ), regulatory T cells (Treg), myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, dendritic cells (DCs), monocytes, neutrophils, T lymphocytes, B cells, and heterogenic population of tumor cells. Reciprocal communication within cellular compartment is accomplished through the paracrine network.