Table 1.
Proteins involve in location-dependent NMDAR signaling activation.
| Protein | Location of stimulated NMDA receptor | NMDA receptor activation induces ↑ or ↓ | Closest partners upstream | Reference |
|---|---|---|---|---|
| CREB | Syn | ↑ | CBP phosphorylation by CaMKIV | [42, 43] |
| Extrasyn | ↓ | CREB dephosphorylation by Jacob | [39] | |
|
| ||||
| ERK 1/2 (MEK phosphorylation) | Syn | ↑ | Ras-GTP | [32, 44] |
| Extra | ↓ | Ras-GDP by SynGAP | ||
|
| ||||
| Ras | Syn | ↑ | Increase in Ca2+ Ras-GTP | [32, 44] |
| Extrasynaptic | ↓ | Less Ca2+
Ras-GDP |
||
|
| ||||
| FOXO1/FOXO3 (transcription factor, apoptosis inducer) | Syn | ↓ | FOXO1/3 phosphorylation by akt inducing nuclear export | [35] |
| Extrasynaptic | ↑ | FOXO3a nuclear translocation | [45] | |
|
| ||||
| Calpain | Extrasynaptic | ↑ | Calpain Ca2+ activated | [46] |
|
| ||||
| STEP | Extrasynaptic | ↑ | STEP cleaved by calpain | [36] |
|
| ||||
| NCX3 | Extrasynaptic | ↑ | NCX3 cleaved by calpain | [21] |
|
| ||||
| Akt/PI3K | Syn | ↑ | Akt/PI3K activated through IRS-1 | [35, 47, 48] |
|
| ||||
| SynGap | Syn | ↑ | Activated by CamKII | [49] |
|
| ||||
| CaMKII | Syn | ↑ | Increase in Ca2+ | [50] |