Fig. 5. Representative brain spectra of glioma patients by using short TE and long TE methods at 3T.

Spectra from IDH-MT glioma patient (A, B) are compared with those from IDH-WT glioma patient (C, D). For all spectra, correct diagnostic results were obtained by LCModel (i.e., 2HG-positive for A and B, and 2HG-negative for C and D). Compared to spectra from normal human brain (Fig. 3), Cho/NAA ratios were substantially increased in these glioma patients. Cho = choline, Cr = creatine, GABA = gamma-aminobutylic acid, Gln = glutamine, Glu = glutamate, IDH-MT = isocitrate dehydrogenase-mutated, IDH-WT = isocitrate dehydrogenase wild-type, Lac = lactate, mI = myo-inositol, NAA = N-acetylaspartate, NAAG = N-acetylaspartylglutamate, TE = echo time, 2HG = 2-hydroxyglutarate