Table 5. Diagnostic Performance for Prediction of Malignant Thyroid Nodules in Korean Thyroid Imaging Reporting and Data System.
| Category | Overall | Sensitivity | Specificity | PPV | NPV | Accuracy | |
|---|---|---|---|---|---|---|---|
| Benign | Malignancy | ||||||
| Overall | 636 | 266 | |||||
| Category 5 | 76 | 210 | 78.9% (210/266) | 88.1% (560/636) | 73.4% (210/286) | 90.9% (560/616) | 85.4% (770/902) |
| Category 4 + 5 | 263 | 254 | 95.5% (254/266) | 58.6% (373/636) | 44.5% (254/517) | 96.9% (373/385) | 69.5% (627/902) |
| Category 3 + 4 + 5 | 591 | 266 | 100.0% (266/266) | 7.1% (45/636) | 31.0% (266/857) | 100.0% (45/45) | 34.5% (311/902) |
| Macro-nodules (≥ 10 mm) | 485 | 101 | |||||
| Category 5 | 28 | 67 | 66.3% (67/101) | 94.2% (457/485) | 70.5% (67/95) | 93.1% (457/491) | 89.4% (524/586) |
| Category 4 + 5 | 156 | 94 | 93.1% (94/101) | 67.8% (329/485) | 37.6% (94/250) | 97.9% (329/336) | 72.2% (423/586) |
| Category 3* + 4 + 5 | 347 | 101 | 100.0% (101/101) | 28.5% (138/485) | 22.5% (101/448) | 100.0% (138/138) | 40.8% (239/586) |
| Micro-nodules (< 10 mm) | 151 | 165 | |||||
| Category 5 | 48 | 143 | 86.7% (143/165) | 68.2% (103/151) | 74.9% (143/191) | 82.4% (103/125) | 77.8% (246/316) |
*Category 3 nodules were included when nodule size was ≥ 15 mm. NPV = negative predictive value, PPV = positive predictive value