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. 2016 Aug 3;6:100–107. doi: 10.1016/j.bbacli.2016.08.001

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — Assay characterization. Linearity and reproducibility of the luminometric signal was tested by (A), using a monoclonal BMP7 antibody; (B), by serial dilutions of positive and negative serum samples (positive, black; negative, grey); and (C), by a commercial polyclonal antibody against BMP2. Nearly linear signals spanning a wide range of concentrations were recorded for both the monoclonal antibody and the BMP7-aAB positive sera derived from the cohort of fracture patients (# 11, 12, 14). The signals obtained from the negative sera (# 7, 10, 9) identified in the same cohort of fracture patients are constant over the whole dilution range. (C) The BMP2-aAB assay was tested by a serial dilution of a polyclonal BMP2 antibody yielding a similar detection range as in the BMP7 assay. n = 2; mean ± SD.