Table 1. Cone response parameters from transretinal recordings.
| control (n = 14) | Nckx2−/− (n = 15) | p-value | |
|---|---|---|---|
| Dark-adapted response | |||
| Time to peak (ms) | 110 ± 4 | 171 ± 6 | 0.001 |
| Integration time (ms) | 203 ± 21 | 391 ± 28 | 0.001 |
| Recovery time constant (ms) | 111 ± 14 | 287 ± 30 | 0.001 |
| Rmax (μV) | 15 ± 1 | 12 ± 1 | 0.01 |
| Io (photons μm−2) | 2,310 ± 320 | 2,650 ± 340 | 0.48 |
| Light-adapted response | |||
| Ib (photons μm−2) | 115,000 ± 39,000 | 66,000 ± 17,000 | 0.27 |
| Hill coefficient | 0.58 ± 0.01 | 0.59 ± 0.03 | 0.96 |
The kinetic parameters were measured from dim flash responses with amplitude less than 20% Rmax. The step light intensity Ib that produced half-maximal response amplitude and the Hill coefficient k were obtained from the light adaptation experiments shown in Fig. 4C. Statistical analyses were made with Student’s t-test. Values given as mean ± SEM. All recordings were from Gnat1-deficient mice.