Figure 11. MAPK signaling pathway is involved in the protective effects of CsA and FK506 on cultured mouse podocytes in vitro.

(A) CsA pretreatment (5 μg/ml) inhibited phospho-p38 and phospho-JNK activation while activating phospho-ERK in PAN-treated podocytes (*P < 0.05, **P < 0.01). (B) FK506 pretreatment (10 μg/ml) inhibited phospho-p38 and activated phospho-ERK in PAN-treated podocytes, but had no effect on the activation of phospho-JNK (*P < 0.05, **P < 0.01). All experiments were performed for 3 times, and the results were shown as mean ± SD.