Table 2. Geometric mean antibody concentration (μg/mL) for polysaccharide pneumococcal serotypes.
Serotype | W 0 IgG GMCb (95% CI) | pa | W 8 IgG GMCb (95% CI) | pa | W 28 IgG GMCb (95% CI) | pa | |||
---|---|---|---|---|---|---|---|---|---|
PCV13 + PPSV23 n = 27 | PPSV23 n = 33 | PCV13 + PPSV23 n = 26 | PPSV23 n = 28 | PCV13 + PPSV23 n = 26 | PPSV23 n = 27 | ||||
1 | 0.17 (0.05–0.37) | 0.14 (0.09–0.19) | 0.59 | 0.86 (0.51–1.94) | 0.73 (0.45–1.17) | 0.45 | 0.48 (0.25–0.77) | 0.30 (0.21–0.43) | 0.05 |
3 | 0.38 (0.11–1.07) | 0.47 (0.26–0.87) | 0.77 | 2.16 (1.21–3.42) | 1.18 (0.60–2.30) | 0.06 | 1.21 (0.84–1.98) | 0.56 (0.33–0.95) | 0.02 |
4 | 0.12 (0.05–0.15) | 0.11 (0.08–0.15) | 0.77 | 0.82 (0.33–1.26) | 0.35 (0.19–0.64) | 0.08 | 0.41 (0.23–0.57) | 0.17 (0.12–0.24) | 0.01 |
5 | 0.18 (0.05–0.40) | 0.15 (0.10–0.24) | 0.77 | 1.68 (0.84–4.77) | 1.01 (0.49–2.09) | 0.35 | 0.83 (0.44–1.97) | 0.42 (0.21–0.81) | 0.09 |
6B | 0.18 (0.05–0.44) | 0.18 (0.11–0.27) | 0.84 | 1.56 (0.84–3.67) | 0.81 (0.33–1.99) | 0.20 | 0.82 (0.33–2.03) | 0.49 (0.25–0.96) | 0.18 |
7F | 0.51 (0.24–0.29) | 0.49 (0.33–0.71) | 0.61 | 1.97 (0.80–4.38) | 2.14 (1.29–3.54) | 0.89 | 1.34 (0.72–2.19) | 1.21 (0.80–1.86) | 0.77 |
9V | 0.29 (0.16–0.63) | 0.27 (0.17–0.44) | 0.7524 | 1.97 (0.90–4.38) | 1.17 (0.63–2.18) | 0.19 | 0.99 (0.52–2.09) | 0.70 (0.38–1.25) | 0.44 |
14 | 0.44 (0.16–0.63) | 1.04 (0.57–1.90) | 0.07 | 4.61 (1.88–20.96) | 5.71 (3.15–10.36) | 0.93 | 2.91 (1.24–8.15) | 3.44 (2.03–5.81) | 0.91 |
18C | 0.17 (0.05–0.27) | 0.32 (0.20–0.52) | 0.06 | 3.67 (0.85–13.36) | 1.81 (0.98–3.36) | 0.20 | 1.44 (0.42–5.39) | 1.08 (0.58–2.01) | 0.73 |
19A | 0.52 (0.32–0.27) | 0.66 (0.40–1.10) | 0.61 | 3.69 (1.65–10.80) | 3.48 (1.63–7.40) | 0.72 | 1.94 (0.84–4.11) | 2.11 (1.10–4.02) | 0.92 |
19F | 0.43 (0.24–0.64) | 0.45 (0.28–0.71) | 0.45 | 2.90 (1.64–4.7) | 1.54 (0.86–2.76) | 0.18 | 1.51 (1.05–1.99) | 0.88 (0.57–1.36) | 0.04 |
23F | 0.25 (0.05–0.92) | 0.17 (0.11–0.28) | 0.45 | 3.20 (0.86–14.44) | 0.55 (0.28–1.07) | <0.01 | 1.55 (0.63–4.78) | 0.42 (0.24–0.75) | 0.01 |
Abbreviations: W, week; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine, n, number of patients with valid assay results for the specified serotype.
aStudent test or Wilcoxon test.
bGMCs were calculated using all subjects with available data for the specified blood collection. GMCs expressed as micrograms per millilitre (μg/mL).