Table 3. Geometric mean antibody titres (ug/ml) for pneumococcal OPA.
| Serotype | W0 GMT (95% CI) | pa | Week 8 GMT (95% CI) | pa | Week 28 GMT (95% CI) | pa | |||
|---|---|---|---|---|---|---|---|---|---|
| PCV13 + PPSV23 n = 27 | PPSV23 n = 33 | PCV13 + PPSV23 n = 26 | PPSV23 n = 28 | PCV13 + PPSV23 n = 26 | PPSV23 n = 27 | ||||
| 1 | 4.98 (4.07–6.08) | 4.80 (4.02–5.73) | 0.89 | 27.35 (13.97–53.54) | 33.42 (18.11–61.66) | 0.85 | 12.20 (7.31–20.37) | 12.34 (8.51–17.91) | 0.29 |
| 3 | 5.28 (3.63–7.69) | 5.28 (3.80–7.32) | 0.91 | 19.53 (11.78–32.37) | 13.36 (7.46–23.93) | 0.66 | 6.91 (4.50–10.61) | 5.95 (4.33–8.18) | 0.36 |
| 4 | 10.19 (4.48–23.17) | 6.77 (3.66–12.53) | 0.67 | 938 (397–2216) | 431 (153–1218) | 0.26 | 281 (95.08–828) | 50.05 (15.96–157) | 0.26 |
| 5 | 5.39 (4.10–7.09) | 4.42 (3.79–5.16) | 0.24 | 55.19 (27.21–112) | 24.60 (12.12–49.93) | 0.80 | 22.02 (11.73–41.34) | 10.36 (5.94–18.09) | 0.19 |
| 6A | 8.14 (3.98–16.66) | 9.89 (4.83–20.25) | 0.66 | 618 (238–1607) | 38.55 (13.44–111) | <0.01 | 209 (72.90–598) | 23.02 (7.95–66.66) | 0.05 |
| 6B | 68.12 (16.63–279) | 81.54 (22.04–302) | 0.82 | 738 (250–2178) | 717 (253–2028) | 0.40 | 522 (184–1479) | 643 (266–1553) | 0.68 |
| 7F | 11.87 (5.10–27.64) | 10.19 (4.97–20.91) | 0.81 | 1354 (809–2267) | 613 (295–1277) | 0.21 | 395 (191–816) | 142 (47.69–424) | 0.88 |
| 9V | 94.74 (26.67–337) | 73.21 (24.02–223) | 0.66 | 1324 (701–2502) | 955 (386–2363) | 0.65 | 1193 (772–1844) | 292 (95.85–892) | 0.31 |
| 14 | 190 (57.69–624.9) | 414 (222–773) | 0.24 | 2544 (1721–3762) | 1266 (827–1938) | 0.11 | 1010 (541–1886) | 375 (185 762) | 0.03 |
| 18C | 13.69 (4.84–38.74) | 7.92 (3.87–16.21) | 0.81 | 1090 (466–2551) | 295 (108–806) | 0.23 | 225 (78.75–645) | 97.45(34.98272) | 0.20 |
| 19A | 8.84 (5.44–14.38) | 17.64 (9.78–31.81) | 0.30 | 239 (127–452) | 228 (127–408) | 0.55 | 88.37 (48.72–160) | 85.80 (46.80–157) | 0.76 |
| 19F | 10.41 (6.22–17.42) | 13.24 (7.12–24.60) | 0.31 | 274 (134–560) | 157 (80.43–305) | 0.47 | 57.10 (30.79–106) | 30.66 (16.42–57.25) | 0.50 |
| 23F | 7.68 (3.90–15.10) | 7.16 (4.03–12.74) | 0.81 | 331 (128–856) | 31.65 (11.79–85.00) | 0.06 | 99.02 (37.64–261) | 18.32 (8.50–39.52) | 0.03 |
Abbreviations: W, week; PCV 13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine; number of patients with valid assay results for the specified serotype.
aStudent test or Wilcoxon test b GMTs were calculated using all subjects with available data for the specified blood collection.