Table 3. Functional changes after 1 year, by dystrophin quantity.
Functional change at 1 year | Dystrophin (% of control) | n | Mean change ± SD | Median change (range) | Correlation between dystrophin % and functional change |
---|---|---|---|---|---|
6MWT distance (m) | 0–33 | 11 | −21 ± 62 | −9 (−170~52) | ρ = 0.3, p = 0.055 |
34–66 | 8 | 4 ± 31 | 1.5 (−29~51) | ||
67–100 | 23 | 18 ± 75 | 10 (−90~273) | ||
NSAA score | 0–33 | 11 | −0.91 ± 1.58 | −1 (−5~1) | ρ = 0.025, p = 0.09 |
34–66 | 10 | −0.8 ± 1.82 | 0 (−5~1) | ||
67–100 | 24 | −0.38 ± 0.93 | 0 (−4~0) | ||
Run/walk 10 m velocity (m/s) | 0–33 | 11 | −0.03 ± 0.41 | 0 (−0.83~0.83) | ρ = 0.22, p = n.s. |
34–66 | 8 | −0.13 ± 0.7 | 0 (−1.67~0.83) | ||
67–100 | 23 | 0.09 ± 0.67 | 0 (−1.67~2.5) | ||
Rise from floor velocity (s−1) | 0–33 | 7 | 0.16 ± 0.24 | 0 (0~0.5) | ρ = 0.07, p = n.s. |
34–66 | 7 | −0.01 ± 0.1 | 0 (−0.17~0.17) | ||
67–100 | 22 | 0.07 ± 0.32 | 0 (−0.5~0.8) | ||
Climb stairs velocity (steps/s) | 0–33 | 10 | 0 ± 0.26 | 0 (−0.29~0.67) | ρ = 0.06, p = n.s. |
34–66 | 9 | 0.11 ± 0.33 | 0 (−0.33~0.67) | ||
67–100 | 22 | −0.35 ± 0.83 | 0 (−2~0.67) |
6MWT: 6 Minute Walk Test. NSAA: North Star Ambulatory Assessment.