Figure 3. Inhibition of caspase-9 attenuated apoptotic cell death mediated by Hif-1α dependent oxidative stress in HepG2 cells.
CYP2E1 and Hif-1α protein level (A), formation of MDA (B), BAX (C) and BCL-XL (D) mRNA levels, and caspase-9 and cleaved PARP protein levels (E) were evaluated in HepG2 cells. Data presented are expressed as Mean ± SD (n = 6) and experimental groups marked by different letters represent significant differences between groups at p < 0.05 (e.g. a and b mean a statistical significant difference between each other).