Figure 2. Effect of ccpA deletion on virulence of GAS serotype strains in mouse models of infection.

CD-1 swiss mice were inoculated with GAS strains by intraperitoneal (a) or intranasal (b) route. Mice were monitored to near-mortality for the bacteremia model (a) and survival was graphed. For the oropharyngeal model (b), throat swabs were obtained daily and the bacterial density was graphed. P values were derived from repeated measures analysis (see Methods).