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. 2016 Jul 14;17(9):1292–1303. doi: 10.15252/embr.201642463

Figure 5. HFD‐induced reprogramming is counteracted by antibiotic treatment.

Figure 5

  1. Cecum of mice treated with or without antibiotics for 6 weeks.
  2. Body weight of animals fed CC or HFD and treated with or without antibiotics for 6 weeks. Animals were fed CC or HFD during the experiment (n = 8 HF and CC control, n = 18 HF and CC + antibiotic; HFD control versus HF antibiotic: Student's t‐test, *P < 0.05; HF antibiotic versus CC antibiotic: unpaired, two‐tailed Student's t‐test, # P < 0.05). Error bars represent SEM.
  3. Gene expression of Pparg and PPARγ target genes in the liver of mice fed CC or HFD for 6 weeks and simultaneously treated with an antibiotic cocktail (n = 4 for each antibiotic‐untreated group, n = 9 for each antibiotic‐treated group, per ZT; ZT0 and ZT12 two‐way ANOVA, post hoc Holm–Sidak comparisons, *P < 0.05, **P < 0.01, ***P < 0.001). Error bars represent SEM.