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. 2016 Feb 29;25(9):1846–1856. doi: 10.1093/hmg/ddw059

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Figure 5. — Effect of DNM1L variants on mitochondrial brain trafficking. (A) Left, Drosophila larval brain ventral nerve cord on with normal mitochondrial distribution. DNM1L^(Ref) was expressed by D42-Gal4 in a sensitized background (Drp1¹/+). Center, mitochondrial trafficking in the axon at the A5 abdominal segment. Right, mitochondria in the synaptic bouton counterstained with HRP (blue) and Discs Large (DLG, red). (B and C) Expression of DNM1L^(A395D) and DNM1L^(G350R) dramatically alter distribution of mitochondria with a defect in trafficking mitochondria. (D) A defect in mitochondrial trafficking observed in the synaptic boutons of DNM1L^(E379K)-expressing larvae. (E) Quantification of number of mitochondria per axon area for A5 axonal segments for the experiment shown in (A)–(D). (F) Quantification of number of mitochondrial per synaptic bouton for the experiment shown in (A)–(D).