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. 2015 Sep 10;24(22):6417–6427. doi: 10.1093/hmg/ddv352

Figure 7.

Figure 7.

AEB1102 dose studies in cynomolgus monkeys. (A) The concentration of AEB1102 and plasma arginine levels are shown for monkeys after single and repeat intravenous dosing at 0.1 mg/kg (semi-log scale). Doses were administered at Days 1 and 8. The solid-filled circles represent Monkey #1 and unfilled circles represent Monkey #2. (B) The concentration of AEB1102 and plasma arginine levels are shown in monkeys after single and repeat intravenous dosing at 0.3 mg/kg (semi-log scale). Doses were administered at Days 1 and 8. The solid-filled squares represent Monkey #1 and unfilled squares represent Monkey #2. (C) The concentration of AEB1102 and plasma arginine levels in monkeys are shown after single and repeat intravenous dosing at 1 mg/kg (semi-log scale). Doses were administered at Days 1 and 8. The solid-filled triangles represent Monkey #1 and unfilled triangles represent Monkey #2.