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. 2016 Mar 16;214(1):114–121. doi: 10.1093/infdis/jiw090

Figure 1.

Figure 1.

Effects of statins on Rhizopus oryzae growth. A, Germination of the R. oryzae isolate RO-969 with no treatment (control) and after treatment with fluconazole (FLU; 64 µg/mL), amphotericin B (AMB; 1 µg/mL), and 2 concentrations of lovastatin (LOV; 16 µg/mL and 128 µg/mL). Magnification ×40. B, Growth of R. oryzae after 48 hours of incubation at 37°C on drug-free and LOV-containing (8 µg/mL and 32 µg/mL) yeast extract agar glucose (YAG) plates. C, Growth inhibition of R. oryzae grown on LOV-containing YAG plates (0, 8, and 32 µg/mL) after exposure to peroxide. Significantly higher susceptibility to peroxide was observed in R. oryzae grown on the YAG plates containing 32 µg/mL LOV, compared with that grown on drug-free YAG plates (*P < .05, by the Kruskal–Wallis test). Data represent mean values (SD) of 3 experiments. Abbreviation: NS, not significant.