Table 1.
Pharmacokinetic parameters of simvastatin and the first-line TB drugs in BALB/c mice following a single oral dose (SD) or at steady-state (SS)
| Drug | Dose (mg/kg) | SD or SS | Co-drugs | Cmax (mg/L) | AUC (mg·h/L) |
|---|---|---|---|---|---|
| Simvastatin acid (dosed as simvastatin) | 20 | SS | none | 0.3 | 0.4 |
| 60 | SS | none | 0.7 | 1.5 | |
| 60 | SS | isoniazid/rifampicin/pyrazinamide | 1.5 | 3.0 | |
| Isoniazid | 10 | SD | rifampicin/pyrazinamide | 3.2 | 4.5 |
| 10 | SS | rifampicin/pyrazinamide | 5.1 | 5.4 | |
| 10 | SS | rifampicin/pyrazinamide + simvastatin | 2.0 | 4.1 | |
| Rifampicin | 10 | SD | isoniazid/pyrazinamide | 9.5 | 102 |
| 10 | SS | isoniazid/pyrazinamide | 10.7 | 132 | |
| 10 | SS | isoniazid/pyrazinamide + simvastatin | 10.1 | 118 | |
| Pyrazinamide | 150 | SD | isoniazid/rifampicin | 180 | 306 |
| 150 | SS | isoniazid/rifampicin | 192 | 232 | |
| 150 | SS | isoniazid/rifampicin + simvastatin | 179 | 394 |
Data represent average values for three animals.