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Sterilizing activity of simvastatin in combination with the first-line regimen against chronic TB in mice
| Regimen | Percentage relapse assessed 12 weeks after the completion of treatment for |
||
|---|---|---|---|
| 2.5 months | 3.5 months | 4.5 months | |
| Isoniazid/rifampicin/pyrazinamide | 100 (10/10) | 50 (5/10) | 0 (15/15) |
| Isoniazid/rifampicin/pyrazinamide + simvastatin | 50 (5/10) | 20 (2/10) | 0 (15/15) |
Relapse is defined as having culture-positive lungs at the time of assessment.
