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. 1996 Oct;49(10):802–804. doi: 10.1136/jcp.49.10.802

Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis.

J A Hammerling 1, R S Lambrecht 1, K S Kehl 1, D R Carrigan 1
PMCID: PMC500772  PMID: 8943744

Abstract

AIMS/BACKGROUND: Human herpesvirus type 6 (HHV-6) is the aetiological agent of exanthem subitum, and has also been linked with a variety of other diseases. The aim of this study was to investigate the role of HHV-6 in pneumonitis in children. METHODS: Formalin fixed, paraffin wax embedded lung tissue from 33 children (age range two months to 16 years) who died with pneumonitis was subjected to immunohistochemical staining for HHV-6 using an avidin-biotin method. RESULTS: Active HHV-6 infection was demonstrated in four children: a bone marrow transplant recipient with concomitant adenovirus infection, a patient with hepatitis of unknown aetiology, a patient with congenital anomalies, and a patient with congenital immunodeficiency. CONCLUSION: Accurate localisation of HHV-6 is possible in postmortem lung tissue. HHV-6 either alone or in combination with other pathogens may play a role in the development of pneumonitis.

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Selected References

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  1. Asano Y., Yoshikawa T., Suga S., Yazaki T., Kondo K., Yamanishi K. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet. 1990 Apr 7;335(8693):862–863. doi: 10.1016/0140-6736(90)90983-c. [DOI] [PubMed] [Google Scholar]
  2. Burd E. M., Carrigan D. R. Human herpesvirus 6 (HHV-6)-associated dysfunction of blood monocytes. Virus Res. 1993 Jul;29(1):79–90. doi: 10.1016/0168-1702(93)90127-9. [DOI] [PubMed] [Google Scholar]
  3. Carrigan D. R., Drobyski W. R., Russler S. K., Tapper M. A., Knox K. K., Ash R. C. Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation. Lancet. 1991 Jul 20;338(8760):147–149. doi: 10.1016/0140-6736(91)90137-e. [DOI] [PubMed] [Google Scholar]
  4. Carrigan D. R., Knox K. K., Tapper M. A. Suppression of human immunodeficiency virus type 1 replication by human herpesvirus-6. J Infect Dis. 1990 Oct;162(4):844–851. doi: 10.1093/infdis/162.4.844. [DOI] [PubMed] [Google Scholar]
  5. Hall C. B., Long C. E., Schnabel K. C., Caserta M. T., McIntyre K. M., Costanzo M. A., Knott A., Dewhurst S., Insel R. A., Epstein L. G. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med. 1994 Aug 18;331(7):432–438. doi: 10.1056/NEJM199408183310703. [DOI] [PubMed] [Google Scholar]
  6. Knox K. K., Carrigan D. R. Disseminated active HHV-6 infections in patients with AIDS. Lancet. 1994 Mar 5;343(8897):577–578. doi: 10.1016/s0140-6736(94)91524-5. [DOI] [PubMed] [Google Scholar]
  7. Knox K. K., Carrigan D. R. HHV-6 and CMV pneumonitis in immunocompromised patients. Lancet. 1994 Jun 25;343(8913):1647–1647. [PubMed] [Google Scholar]
  8. Knox K. K., Pietryga D., Harrington D. J., Franciosi R., Carrigan D. R. Progressive immunodeficiency and fatal pneumonitis associated with human herpesvirus 6 infection in an infant. Clin Infect Dis. 1995 Feb;20(2):406–413. doi: 10.1093/clinids/20.2.406. [DOI] [PubMed] [Google Scholar]
  9. Lusso P., Ensoli B., Markham P. D., Ablashi D. V., Salahuddin S. Z., Tschachler E., Wong-Staal F., Gallo R. C. Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature. 1989 Jan 26;337(6205):370–373. doi: 10.1038/337370a0. [DOI] [PubMed] [Google Scholar]
  10. Pellett P. E., Black J. B., Yamamoto M. Human herpesvirus 6: the virus and the search for its role as a human pathogen. Adv Virus Res. 1992;41:1–52. doi: 10.1016/s0065-3527(08)60034-2. [DOI] [PubMed] [Google Scholar]
  11. Pitalia A. K., Liu-Yin J. A., Freemont A. J., Morris D. J., Fitzmaurice R. J. Immunohistological detection of human herpes virus 6 in formalin-fixed, paraffin-embedded lung tissues. J Med Virol. 1993 Oct;41(2):103–107. doi: 10.1002/jmv.1890410204. [DOI] [PubMed] [Google Scholar]
  12. Russler S. K., Tapper M. A., Knox K. K., Liepins A., Carrigan D. R. Pneumonitis associated with coinfection by human herpesvirus 6 and Legionella in an immunocompetent adult. Am J Pathol. 1991 Jun;138(6):1405–1411. [PMC free article] [PubMed] [Google Scholar]
  13. Tajiri H., Nose O., Baba K., Okada S. Human herpesvirus-6 infection with liver injury in neonatal hepatitis. Lancet. 1990 Apr 7;335(8693):863–863. doi: 10.1016/0140-6736(90)90984-d. [DOI] [PubMed] [Google Scholar]
  14. Toorkey C. B., Carrigan D. R. Immunohistochemical detection of an immediate early antigen of human cytomegalovirus in normal tissues. J Infect Dis. 1989 Nov;160(5):741–751. doi: 10.1093/infdis/160.5.741. [DOI] [PubMed] [Google Scholar]

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