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. 2016 Aug 25;5:F1000 Faculty Rev-2077. [Version 1] doi: 10.12688/f1000research.8631.1

Table 2. Frequency of PARP-1 and PARP-2 mutations in Ewing sarcoma.

Study Sequencing platform Patient cohort PARP-1 mutations PARP-2 mutations
Crompton et al. 13 WES n = 92 n = 1 (1.1%) (K203R) n = 2 (E222Q, H428H)
Tirode et al. 56 WGS n = 112 n = 0 (0%) n = 0 (0%)
Agelopoulos et al. 54 WES n = 50 n = 0 (0%) n = 0 (0%)
Huether et al. 55 WGS n = 19 n = 0 (0%) n = 0 (0%)
Brohl et al. 12 WGS n = 6 n = 0 (0%) n = 0 (0%)
Total n = 1/279 (0.36%) n = 2/279 (0.72%)

PARP, poly ADP ribose polymerase; WES, whole exome sequencing; WGS, whole genome sequencing.