Table 2.
Serum indices from nude mice bearing a BxPC-3 xenograft that were treated orally by gavage with either the vehicle control or DFX (120, 160, or 200 mg/kg) every second day (three treatments per week) for 21 days
| Units | Treatment groups | ||||
|---|---|---|---|---|---|
| Vehicle control | Deferasirox | ||||
| 120 mg/kg | 160 mg/kg | 200 mg/kg | |||
| Ferritin | ng/ml | 18.3 ± 1.9 | 20.6 ± 2.9 | 8.6 ± 1.4* | 9.8 ± 1.5* |
| Total protein | g/dl | 5.0 ± 0.3 | 5.4 ± 0.3 | 5.3 ± 0.4 | 5.3 ± 0.3 |
| Albumin | g/dl | 3.2 ± 0.2 | 3.3 ± 0.1 | 3.4 ± 0.1 | 3.4 ± 0.1 |
| Aspartate aminotransferase | U/l | 89.2 ± 15.8 | 106.2 ± 32.6 | 155.2 ± 97.9 | 146 ± 58.9 |
| Alanine transaminase | U/l | 23.6 ± 1.9 | 29.2 ± 8.2 | 28.4 ± 9.6 | 28.8 ± 7.2 |
| Lactate dehydrogenase | U/l | 243.6 ± 37.9 | 242.6 ± 18.2 | 243.8 ± 23.1 | 243.6 ± 21.7 |
| Blood urea nitrogen | mg/dl | 560.6 ± 112.7 | 578.2 ± 65.5 | 669 ± 43.9 | 689.8 ± 101.9 |
| Creatinine | mg/dl | 17.6 ± 1.2 | 14.2 ± 2.1 | 14.4 ± 0.6 | 15.8 ± 1.3 |
*p <0.05 vs. control