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. 2016 Aug 15;5(8):e253. doi: 10.1038/oncsis.2016.47

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Immunohistochemical analyses of RCAN2 in surgical specimens from patients with colorectal cancer (CRC). Representative images of immunohistochemical staining (IHC) at the border between adenoma (right, in a) and adenocarcinoma (left, in a), and the intratumoral distribution of RCAN2 expression (b). Magnified views at the tumor center and the invasive front of tumors (c, d, respectively). Representative IHC images of KRAS wild-type and KRAS-mutated human CRC tissue samples (e, f, respectively). Comparison of IHC-positive cells in the carcinomatous area of KRAS wild-type and KRAS-mutated CRC indicated lower expression of RCAN2 in KRAS-mutated CRC (P=0.0447, g).