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. 2016 Aug 8;5(8):e250. doi: 10.1038/oncsis.2016.52

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Characteristics of hyaluronic acid-poly(ethylene imine)/hyaluronic acid-poly(ethylene glycol) (HA-PEI/HA-PEG) nanoparticles. (a) Schematic representation of HA-PEI/PEG nanoassemblies encapsulated with plasmid DNA. (b) Transmission electron microscopy image of the self-assembling nanoparticles showing a spherical morphology. (c) Parting size and zeta potential (surface charge) analysis of the control and DNA-encapsulated nanoparticles. The hydrodynamic diameter of the particles was in range of 235-410 nm with a polydispersity index (PDI) of 0.2–0.3 and the surface charge was in the range of −33 to −38 mV.