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. 2016 Aug 8;5(8):e250. doi: 10.1038/oncsis.2016.52

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Comparison between differential microRNA (miRNAs) expression in different exosomes extracted from untreated and plasmid DNA-transfected SK-LU-1 cells. (a) Comparison between miRNAs secreted post-treatment of SK-LU-1 cells with individual plasmid expressing wt-p53 (wt-p53/exo) and miRNA-125b (miR-125b/exo). (b) Comparison between miRNAs secreted in exosomes post-treatment of SK-LU-1 cells with individual wt-p53 expressing plasmid (wt-p53/exo) and post-treatment with combination wt-p53 and miR-125b expressing plasmid DNA (combi/exo). (c) Comparison between miRNAs secreted post-treatment of SK-LU-1 cells with individual miR-125b expressing plasmid (miR-125b/exo) and post-treatment with combination miR-125b and wt-p53 expressing plasmid DNA (combi/exo). (d) Comparison of all miRNAs that were commonly expressed between all different treatment groups. About 15 miRNAs were significantly expressed in the exosomes from the transfected cells as compared with the control exosomes from non-transfected SK-LU-1 (SK/exo) groups (P<0.05).